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Nature Communications (2015) 6, 8451Ĭoussens, AK Naude, CE Goliath, R Chaplin, G Wilkinson, RJ and Jablonski, NG.

HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling. Lai, RPJ Meintjes, G Wilkinson, KA Graham, CM Marais, S Van der Plas, H Deffur, A Schutz, C Bloom, C Munagala, I Anguiano, E Goliath, R Maartens, G Banchereau, J Chaussabel, D O'Garra, A and Wilkinson, RJ. Characterization of progressive HIV-associated tuberculosis using 2-deoxy-2-fluoro-D-glucose positron emission and computed tomography. Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages. Stucki, D., Brites, D., Jeljeli, L., Coscolla, M., Liu, Q., Trauner, A., Fenner, L., Rutaihwa, L., Borrell, S., Luo, T., Gao, Q., Kato-Maeda, M., Ballif, M., Egger, M., Macedo, R., Mardassi, H., Moreno, M., Vilanova, G.T., Fyfe, J., Globan, M., Thomas, J., Jamieson, F., Guthrie, J.L., Asante-Poku, A., Yeboah-Manu, D., Wampande, E., Ssengooba, W., Joloba, M., Boom, W.H., Basu, I., Bower, J., Saraiva, M., Vasconcellos, S.E.G., Suffys, P., Koch, A., Wilkinson, R., Gail-Bekker, L., Malla, B., Ley, S.D., Beck, H.-P., De Jong, B.C., Toit, K., Sanchez-Padilla, E., Bonnet, M., Gil-Brusola, A., Frank, M., Penlap Beng, V.N., Eisenach, K., Alani, I., Ndung'U, P.W., Revathi, G., Gehre, F., Akter, S., Ntoumi, F., Stewart-Isherwood, L., Ntinginya, N.E., Rachow, A., Hoelscher, M., Cirillo, D.M., Skenders, G., Hoffner, S., Bakonyte, D., Stakenas, P., Diel, R., Crudu, V., Moldovan, O., Al-Hajoj, S., Otero, L., Barletta, F., Carter, E.J., Diero, L., Supply, P., Comas, I., Niemann, S., Gagneux, S. How does HIV infection influence the immune responses to Mycobacterium tuberculosis in the lung? What is the pathogenesis of tuberculous pericarditis? What is the cause and best management of the HIV-Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome? This project is led by Professor Graeme Meintjes, Professor and Infectious Diseases Physician, CIDRI-Africa, UCT.

How can tuberculosis infection in HIV infected people be more effectively prevented?īy what immune mechanisms do preventive therapies decrease susceptibility to TB? Projects underway at present include the following: Through clinically-based studies, they aim to improve knowledge of pathogenesis and thereby improve prevention and treatment. His research programme derives its research questions from the clinical care of tuberculosis (TB) and HIV-TB co-infected persons in South Africa and London. The epidemiology and clinical features of HIV associated TB are well researched, but few studies have addressed in detail the cellular mechanisms. HIV and TB are the most pressing public health problems in Africa: in South Africa, many hundreds of people still die prematurely per day because of HIV, many due to co-existent TB. Wilkinson’s interests are focused on clinical and immunological aspects of tuberculosis, particularly in the context of HIV-1 infection. Senior Group Leader at The Francis Crick Institute, London and Wellcome Senior Fellow in Clinical Science at Imperial College London Director, Centre for Infectious Diseases Research in Africa (CIDRI-Africa)  Group leader and Director, Crick African Network  and Member, Institute of Infectious Disease and Molecular Medicine Department of Medicine, Faculty of Health Sciences, University of Cape Town Selected publications | Contact details | Group members | Collaborations